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Home > Bcl-2 Protein Inhibitors/Degraders > BCL-2 Selective Inhibitors > ABT-199 (Venetoclax)

ABT-199 (Venetoclax)

BCL-2 is overexpressed in several hematologic malignancies, acting as a key regulator of the intrinsic apoptotic pathway by neutralizing pro-apoptotic molecules and inhibiting apoptosis. ABT-199 is an orally bioavailable, second-generation BH3-mimetic that specifically and potently inhibits BCL-2 (Ki<0.10 nM), highly selective over BCL-xL (Ki=48 nM, a 500-fold selectivity). It is the first small molecule targeting BCL-xL with such selectivity and potency, and currently in clinical trials for cancer treatment.

Catalog NO:	CT-A199
Synonym:	Venectoclax, GDC-0199
CAS NO:	1257044-40-8
Mol. Formula:	C₄₅H₅₀ClN₇O₇S
MW:	868.4 (or, refer to Certificate of Analysis, batch-specific)

** 99.9% pure, in vivo Quality Material. A multi cycle recrystallized yellow powder. Anhydrous, validated by a spot-on Quantitative Elemental Analysis. Bulk stock!! Prompt.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	10 mg	$70.00	YES
2	50 mg	$120.00	YES
3	100 mg	$180.00	YES
4	200 mg	$290.00	YES
5	500 mg	$600.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : 99.9% (HPLC at 214 and 254 nm)

Original QC Data : HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis Report

Please Pick Batch NO:

ABT-199, Lot 09, Certificate of Analysis.pdf

1. A. J. Souers, et al., ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets, Nature Medicine, 19(2), 202-8 (2013)

2. M. S. Davids, et al., ABT-199: Taking Dead Aim at BCL-2, Cancer Cell, Vol 23, Issue 2, 139-141, 11 February 2013

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